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Literature summary extracted from

  • Cooper, P.H.; Hawthorne, J.N.
    Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization (1976), Biochem. J., 160, 97-105.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 ATP above 4 mM Rattus norvegicus
2.7.1.67 cetyltrimethylammonium bromide
-
 Rattus norvegicus
2.7.1.67 Cutsum above 2% v/v Rattus norvegicus
2.7.1.67 sodium deoxycholate
-
 Rattus norvegicus
2.7.1.67 Triton X-100
-
 Rattus norvegicus
2.7.1.68 ATP above 4 mM Rattus norvegicus
2.7.1.68 cetyltrimethylammonium bromide
-
 Rattus norvegicus
2.7.1.68 Cutsum
-
 Rattus norvegicus
2.7.1.68 EDTA slight inhibition between 0.5-5 mM Rattus norvegicus
2.7.1.68 sodium deoxycholate
-
 Rattus norvegicus
2.7.1.68 Triton X-100
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 Golgi apparatus
-
 Rattus norvegicus 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mn2+ the enzyme is dependent on Mg2+ Rattus norvegicus
2.7.1.68 Co2+ 2 mM, activates Rattus norvegicus
2.7.1.68 Fe2+ 2 mM, slight inhibition Rattus norvegicus
2.7.1.68 Mg2+ activates Rattus norvegicus
2.7.1.68 Mg2+ 2 mM, dependent on Rattus norvegicus
2.7.1.68 Mn2+ 2 mM, activates Rattus norvegicus
2.7.1.68 Zn2+ 2 mM, slight inhibition Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Rattus norvegicus
-
-
-
2.7.1.68 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 kidney cortex Rattus norvegicus
-
2.7.1.67 renal cortex
-
 Rattus norvegicus
-
2.7.1.68 kidney cortex Rattus norvegicus
-
2.7.1.68 renal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.67 7.7
-
-
 Rattus norvegicus
2.7.1.68 6.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.67 7.3 9 pH 7.3: about 75% of maximal activity, pH 9.0: about 95% of maximal activity Rattus norvegicus
2.7.1.68 5 8 pH 5.0: about 65% of maximal activity, pH 8.0: about 75% of maximal activity Rattus norvegicus