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Literature summary extracted from

  • Etges, R.; Mukkada, A.J.
    Purification and characterization of a metabolite-regulated pyruvate kinase from Leishmania major promastigotes (1988), Mol. Biochem. Parasitol., 27, 281-289.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.40 D-fructose 1,6-diphosphate activation Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.40 ATP strong Leishmania major
2.7.1.40 citrate
-
 Leishmania major
2.7.1.40 GTP
-
 Leishmania major
2.7.1.40 ITP
-
 Leishmania major
2.7.1.40 additional information no inhibition by several amino acids Leishmania major

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.40 additional information
-
 additional information kinetic study Leishmania major

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.40 K+ activation Leishmania major
2.7.1.40 Mg2+ activation Leishmania major

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.40 59000
-
 x * 59000 Leishmania major
2.7.1.40 181000
-
-
 Leishmania major

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.40 ADP + phosphoenolpyruvate Leishmania major involved in regulation of metabolism of an aerobic organism capable of net glucose synthesis ATP + pyruvate
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate Leishmania major allosteric enzyme ATP + pyruvate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.40 Leishmania major
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.40
-
 Leishmania major

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.40 promastigote
-
 Leishmania major
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.40 ADP + phosphoenolpyruvate positive cooperativity for phosphoenolpyruvate Leishmania major ATP + pyruvate
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate involved in regulation of metabolism of an aerobic organism capable of net glucose synthesis Leishmania major ATP + pyruvate
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate allosteric enzyme Leishmania major ATP + pyruvate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.40 ? x * 59000 Leishmania major

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.40 7
-
 in the absence of fructose 1,6-diphosphate Leishmania major
2.7.1.40 7.6
-
 in the presence of fructose 1,6-diphosphate Leishmania major