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Literature summary extracted from

  • Choudhry, A.E.; Mandichak, T.L.; Broskey, J.P.; Egolf, R.W.; Kinsland, C.; Begley, T.P.; Seefeld, M.A.; Ku, T.W.; Brown, J.R.; Zalacain, M.; Ratnam, K.
    Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections (2003), Antimicrob. Agents Chemother., 47, 2051-2055.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.33 pantothenamide, N-substituted IC50 about 0.0004-0.0016 mM Staphylococcus aureus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.33 0.027
-
 pantothenate pH 7.5, 25°C Staphylococcus aureus
2.7.1.33 0.093
-
 ATP pH 7.5, 25°C Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.33 29100
-
 x * 29100, recombinant enzyme, six-His-tagged Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33 recombinant enzyme, six-His-tagged Staphylococcus aureus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.33 ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate bi bi mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + D-pantothenate
-
 Staphylococcus aureus ADP + D-4'-phosphopantothenate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.33 ? x * 29100, recombinant enzyme, six-His-tagged Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.33 0.0004 0.0016 IC50 about 0.0004-0.0016 mM Staphylococcus aureus pantothenamide, N-substituted