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Literature summary extracted from

  • Bone, R.; Cheng, Y.C.; Wolfenden, R.
    Inhibition of thymidine kinase by P1-(adenosine-5)-P5-(thymidine-5)-pentaphosphate (1986), J. Biol. Chem., 261, 5731-5735.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.21 additional information bisubstrate analogs with adenosine and thymidine joined at their 5' positions by polyphorphoryl linkages of varying lengths can serve as inhibitors Homo sapiens
2.7.1.21 P1-(Adenosine-5')-P3-(thymidine-5')-triphosphate
-
 Homo sapiens
2.7.1.21 P1-(adenosine-5')-P4-(thymidine-5')-tetraphosphate
-
 Homo sapiens
2.7.1.21 P1-(Adenosine-5')-P5-(thymidine-5')-pentaphosphate
-
 Homo sapiens
2.7.1.21 P1-(Adenosine-5')-P6-(thymidine-5')-hexaphosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.21 0.0026
-
 thymidine mitochondrial enzyme, pH 7.5, 37°C Homo sapiens
2.7.1.21 0.01
-
 thymidine cytosolic enzyme, pH 7.5, 37°C Homo sapiens
2.7.1.21 0.07
-
 ATP cytosolic enzyme, pH 7.5, 37°C Homo sapiens
2.7.1.21 0.11
-
 ATP mitochondrial enzyme, pH 7.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.21 cytosol
-
 Homo sapiens 5829
-
2.7.1.21 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.21 blast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + thymidine
-
 Homo sapiens ADP + dTMP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.21 additional information
-
 additional information bisubstrate analogs with adenosine and thymidine joined at their 5' positions by polyphorphoryl linkages of varying lengths Homo sapiens