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Literature summary extracted from

  • Bone, R.; Cheng, Y.C.; Wolfenden, R.
    Inhibition of adenosine and thymidylate kinases by bisubstrate analogs (1986), J. Biol. Chem., 261, 16410-16413.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 adenosine-5'-pentaphospho-5'-adenosine
-
 Homo sapiens
2.7.1.20 adenosine-5'-tetraphospho-5'-adenosine strong inhibition Homo sapiens
2.7.1.20 Bisadenylyl polyphosphates
-
 Homo sapiens
2.7.4.9 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
-
 Homo sapiens
2.7.4.9 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
-
 Homo sapiens
2.7.4.9 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.20 Mg2+ requirement Homo sapiens
2.7.1.20 Mg2+ optimal at Mg: ATP ratio 1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Homo sapiens
-
-
-
2.7.4.9 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.20 ATP + adenosine = ADP + AMP mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 liver
-
 Homo sapiens
-
2.7.4.9 blast cell peripheral blast cell obtained from acute myelocytic leukemia patients Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.20 37
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.20 0.00003
-
 adenosine-5'-tetraphospho-5'-adenosine pH 7.4, 37ºC Homo sapiens
2.7.1.20 0.000073
-
 adenosine-5'-pentaphospho-5'-adenosine pH 7.4, 37ºC Homo sapiens
2.7.4.9 0.00018
-
 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
2.7.4.9 0.0002
-
 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens
2.7.4.9 0.00047
-
 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
2.7.4.9 0.0006
-
 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens
2.7.4.9 0.0175
-
 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
2.7.4.9 0.0209
-
 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens