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Literature summary extracted from

  • De Jong, J.W.
    Partial purification and properties of rat heart adenosine kinase (1977), Arch. Int. Physiol. Biochim., 85, 557-569.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.20 dipyridamole at high adenosine levels Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 8-azaadenosine
-
 Rattus norvegicus
2.7.1.20 dipyridamole at low adenosine levels Rattus norvegicus
2.7.1.20 Mg2+ strong inhibition above 1 mM Rattus norvegicus
2.7.1.20 Mn2+ strong inhibition above 1 mM Rattus norvegicus
2.7.1.20 NSC 113939
-
 Rattus norvegicus
2.7.1.20 NSC 113940
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.20 0.00015 0.0005 adenosine
-
 Rattus norvegicus
2.7.1.20 0.0033
-
 adenosine in the presence of dipyridamol Rattus norvegicus
2.7.1.20 0.1
-
 ATP
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.20 Mg2+ requirement Rattus norvegicus
2.7.1.20 Mg2+ 0.5 mM Rattus norvegicus
2.7.1.20 Mn2+ can partially substitute for Mg2+ Rattus norvegicus
2.7.1.20 Mn2+ activation Rattus norvegicus
2.7.1.20 Mn2+ at 0.5 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.20 39000
-
 myocard Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.20 partial, 80fold purification Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 heart myocard Rattus norvegicus
-
2.7.1.20 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Rattus norvegicus ADP + AMP
-
 ?
2.7.1.20 CTP + adenosine less efficient than ATP Rattus norvegicus CDP + AMP
-
 ?
2.7.1.20 GTP + adenosine better activity than with ATP Rattus norvegicus GDP + AMP
-
 ?
2.7.1.20 ITP + adenosine better activity than with ATP Rattus norvegicus IDP + AMP
-
 ?
2.7.1.20 UTP + adenosine less efficient than ATP Rattus norvegicus UDP + AMP
-
 ?