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Literature summary extracted from

  • Sener, A.; Malaisse, W.J.
    Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release (1996), Biochim. Biophys. Acta, 1312, 73-78.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 D-glucose 6-phosphate noncompetitive inhibition Homo sapiens
2.7.1.1 D-mannoheptulose competitive inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 3.8
-
 D-glucose 30°C, pH 7.5 Homo sapiens
2.7.1.1 4.6
-
 D-mannose 30°C, pH 7.5 Homo sapiens
2.7.1.1 157.7
-
 D-fructose 30°C, pH 7.5 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 ATP + D-glucose Homo sapiens
-
 ADP + D-glucose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Homo sapiens
-
 B-cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 B-cell
-
 Homo sapiens
-
2.7.1.1 pancreatic islet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.1 35.7
-
 D-mannose as substrate Homo sapiens
2.7.1.1 38.1
-
 D-glucose as substrate Homo sapiens
2.7.1.1 98.7
-
 D-fructose as substrate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + 2-deoxy-D-glucose
-
 Homo sapiens ADP + 2-deoxy-D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-fructose
-
 Homo sapiens ADP + D-fructose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Homo sapiens ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-mannose
-
 Homo sapiens ADP + D-mannose 6-phosphate
-
 ?