Literature summary extracted from

Yu, Y.; Sato, J.D.
MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor (1999), J. Cell. Physiol., 178, 235-246.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.137	additional information	vascular endothelial growth factor activates phosphatidylinositol 3-kinase in human umbilical vein endothelial cells. Activities of ERK, PI 3-kinase, and p70 S6 kinase are essential for vascular endothelial growth factor-induced human umbelical vein proliferation	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.137	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.137	endothelium	umbilical vein endothelial cells	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.137	ATP + 1-phosphatidylinositol	-	Homo sapiens	ADP + phosphatidylinositol 3-phosphate	-	?

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Release 2023.1 (January 2023)