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Literature summary extracted from

  • Virbasius, J.V.; Guilherme, A.; Czech, M.P.
    Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain (1996), J. Biol. Chem., 271, 13304-13307.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.154 monocyte chemotactic peptide-1 agonist-induced activation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.137 PI 3-kinase p170 Mus musculus
2.7.1.154 cloned into the baculovirus expression vector pAcG3x and expressed in Sf9 cells Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.154 170000
-
 x * 170000, calculation from nucleotide sequence Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Mus musculus the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Mus musculus
-
-
-
2.7.1.154 Homo sapiens
-
 PI3K-C2alpha
-
2.7.1.154 Homo sapiens PI3K-C2alpha
-
 PI3K-C2alpha
-
2.7.1.154 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 adipocyte insulin-sensitive mouse 3T3-L1 adipocytes Mus musculus
-
2.7.1.154 3T3-L1 cell adipocyte Mus musculus
-
2.7.1.154 THP-1 cell monocyte Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Mus musculus ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 additional information the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.154 ?
-
 Homo sapiens
2.7.1.154 ? x * 170000, calculation from nucleotide sequence Mus musculus