Literature summary extracted from

Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes (2001), J. Biol. Chem., 276, 2494-2502.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.137	additional information	thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.137	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.137	cell culture	BAF3 cells and primary murine megakaryocyte	Mus musculus	-
2.7.1.137	megakaryocyte	primary	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.137	ATP + 1-phosphatidylinositol	-	Mus musculus	ADP + phosphatidylinositol 3-phosphate	-	?

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Release 2023.1 (January 2023)