Literature summary extracted from

Axelsson, L.; Hellberg, C.; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.
Clustering of b2-Integrins on Human Neutrophils Activates Dual Signaling Pathways to PtdIns 3-Kinase (2000), Exp. Cell Res., 256, 257-263.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.137	additional information	b2-integrins activate the tyrosine kinases p58c-fgr and p59/61hck and causes them to associate with the p85 subunit of PtdIns 3-kinase. Thus, even if PtdIns 3-kinase is not activated by p21ras, it can maintain full enzyme activity due to the interaction with p58c-fgr or p59/61hck	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.137	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.137	ATP + 1-phosphatidylinositol	-	Homo sapiens	ADP + phosphatidylinositol 3-phosphate	-	?

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Release 2023.1 (January 2023)