BRENDA - Enzyme Database

Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases

Shibasaki, F.; Fukui, Y.; Takenawa, T.; Biochem. J. 289, 227-231 (1993)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.137
phosphatidic acid
enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I
Bos taurus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.137
adenosine
above 0.1 mM
Bos taurus
2.7.1.137
ADP
above 0.1 mM
Bos taurus
2.7.1.137
AMP
above 0.1 mM
Bos taurus
2.7.1.137
cardiolipin
-
Bos taurus
2.7.1.137
isoquercetin
PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II
Bos taurus
2.7.1.137
phosphatidylcholine
strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI
Bos taurus
2.7.1.137
quercetin
inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive
Bos taurus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.137
additional information
Bos taurus
enzyme plays an important role in the signalling of cell growth
?
-
-
-
2.7.1.137
additional information
Bos taurus
enzyme plays an important role in the signaling of cell growth
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.137
Bos taurus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.137
phosphoprotein
putative PI 3-kinase 85000 Da subunit is phosphorylated by pp60vscr
Bos taurus
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.137
PI3KII, heterodimeric form; PI3KI, monomeric form
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.137
thymus
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.137
ATP + 1-phosphatidylinositol
-
640854
Bos taurus
ADP + phosphatidylinositol 3-phosphate
-
640854
Bos taurus
?
2.7.1.137
additional information
enzyme plays an important role in the signalling of cell growth
640854
Bos taurus
?
-
-
-
-
2.7.1.137
additional information
enzyme plays an important role in the signaling of cell growth
640854
Bos taurus
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
2.7.1.137
More
two types of PI 3-kinase a monomer form, PI 3-kinase I, and a heterodimeric form, PI 3-kinase II
Bos taurus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.137
phosphatidic acid
enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.137
adenosine
above 0.1 mM
Bos taurus
2.7.1.137
ADP
above 0.1 mM
Bos taurus
2.7.1.137
AMP
above 0.1 mM
Bos taurus
2.7.1.137
cardiolipin
-
Bos taurus
2.7.1.137
isoquercetin
PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II
Bos taurus
2.7.1.137
phosphatidylcholine
strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI
Bos taurus
2.7.1.137
quercetin
inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.137
additional information
Bos taurus
enzyme plays an important role in the signalling of cell growth
?
-
-
-
2.7.1.137
additional information
Bos taurus
enzyme plays an important role in the signaling of cell growth
?
-
-
-
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.137
phosphoprotein
putative PI 3-kinase 85000 Da subunit is phosphorylated by pp60vscr
Bos taurus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.137
PI3KII, heterodimeric form; PI3KI, monomeric form
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.137
thymus
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.137
ATP + 1-phosphatidylinositol
-
640854
Bos taurus
ADP + phosphatidylinositol 3-phosphate
-
640854
Bos taurus
?
2.7.1.137
additional information
enzyme plays an important role in the signalling of cell growth
640854
Bos taurus
?
-
-
-
-
2.7.1.137
additional information
enzyme plays an important role in the signaling of cell growth
640854
Bos taurus
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.1.137
More
two types of PI 3-kinase a monomer form, PI 3-kinase I, and a heterodimeric form, PI 3-kinase II
Bos taurus