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Literature summary extracted from

  • Baxter, R.M.; Bramham, J.; Thomason, P.A.; Downes, C.P.; Carter, A.N.
    Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts (1993), Biochem. Soc. Trans., 21, 359S.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 Nonidet P40
-
 Rattus norvegicus
2.7.1.137 quercetin 5 mM, 70% inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 phosphatidylinositol-4,5-bisphosphate + ATP Rattus norvegicus involved in signalling pathways leading to mitosis and differentiation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 brain
-
 Rattus norvegicus
-
2.7.1.137 cell culture PC12 cells Rattus norvegicus
-
2.7.1.137 cell culture PC 12 cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Rattus norvegicus ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 phosphatidylinositol-4,5-bisphosphate + ATP involved in signalling pathways leading to mitosis and differentiation Rattus norvegicus ?
-
 ?