Literature summary extracted from

Herbst, J.J.; Andrews, G.; Contillo, L.; Lamphere, L.; Gardner, J.; Lienhard, G.E.; Gibbs, E.M.
Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains (1994), Biochemistry, 33, 9376-9381.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.137	Phosphotyrosine peptides	high-affinity activation of the enzyme requires the simultaneous binding of two phosphorylated YMXM motifs on insulin receptor substrate 1 to the two SH2 domains of the phosphatidylinositol 3'-kinase	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.1.137	cytosol	-	Rattus norvegicus	5829	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.137	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.137	adipocyte	3T3-L1	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.137	ATP + 1-phosphatidylinositol	-	Rattus norvegicus	ADP + phosphatidylinositol 3-phosphate	-	?

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Release 2023.1 (January 2023)