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Literature summary extracted from

  • Stephens, L.R.; Hawkins, P.T.; Morris, A.J.; Downes, C.P.
    L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase (1988), J. Biol. Chem., 249, 283-292.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.134 soluble
-
 Mus musculus
-
-
2.7.1.134 soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.134 29000
-
 brain enzyme, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.134 Mus musculus
-
-
-
2.7.1.134 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.134 ammonium sulfate, brain enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.134 brain
-
 Rattus norvegicus
-
2.7.1.134 heart
-
 Rattus norvegicus
-
2.7.1.134 liver
-
 Rattus norvegicus
-
2.7.1.134 macrophage bone marrow Mus musculus
-
2.7.1.134 parotid gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.134 additional information
-
 specific activities of various rat tissues Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate Mus musculus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position Mus musculus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.134 37
-
 assay at Mus musculus
2.7.1.134 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.134 7
-
 assay at Mus musculus
2.7.1.134 7
-
 assay at Rattus norvegicus