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Literature summary extracted from

  • Conti, M.A.; Adelstein, R.S.
    Purification and properties of myosin light chain kinases (1991), Methods Enzymol., 196, 34-47.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.11.18 repeated freeze-thawing decreases activity Meleagris gallopavo
2.7.11.18 repeated freeze-thawing decreases activity Homo sapiens
2.7.11.18 repeated freeze-thawing decreases activity Rattus norvegicus
2.7.11.18 repeated freeze-thawing decreases activity Sus scrofa
2.7.11.18 repeated freeze-thawing decreases activity Bos taurus
2.7.11.18 repeated freeze-thawing decreases activity Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 phosphorylation
-
 Bos taurus
2.7.11.18 phosphorylation
-
 Homo sapiens
2.7.11.18 phosphorylation
-
 Meleagris gallopavo
2.7.11.18 phosphorylation
-
 Oryctolagus cuniculus
2.7.11.18 phosphorylation
-
 Rattus norvegicus
2.7.11.18 phosphorylation
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.18 myofibril associated Meleagris gallopavo 30016
-
2.7.11.18 myofibril associated Homo sapiens 30016
-
2.7.11.18 myofibril associated Rattus norvegicus 30016
-
2.7.11.18 myofibril associated Sus scrofa 30016
-
2.7.11.18 myofibril associated Bos taurus 30016
-
2.7.11.18 myofibril associated Oryctolagus cuniculus 30016
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Meleagris gallopavo
2.7.11.18 Ca2+
-
 Homo sapiens
2.7.11.18 Ca2+
-
 Rattus norvegicus
2.7.11.18 Ca2+
-
 Sus scrofa
2.7.11.18 Ca2+
-
 Bos taurus
2.7.11.18 Ca2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Meleagris gallopavo
-
 ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Homo sapiens
-
 ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Rattus norvegicus
-
 ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Sus scrofa
-
 ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Bos taurus
-
 ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Oryctolagus cuniculus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Bos taurus
-
-
-
2.7.11.18 Homo sapiens
-
-
-
2.7.11.18 Meleagris gallopavo
-
-
-
2.7.11.18 Oryctolagus cuniculus
-
-
-
2.7.11.18 Rattus norvegicus
-
-
-
2.7.11.18 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.18
-
 Meleagris gallopavo
2.7.11.18
-
 Homo sapiens
2.7.11.18
-
 Bos taurus
2.7.11.18
-
 Oryctolagus cuniculus
2.7.11.18 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 brain
-
 Sus scrofa
-
2.7.11.18 brain
-
 Bos taurus
-
2.7.11.18 gizzard
-
 Meleagris gallopavo
-
2.7.11.18 myometrium
-
 Sus scrofa
-
2.7.11.18 pancreas
-
 Rattus norvegicus
-
2.7.11.18 platelet
-
 Homo sapiens
-
2.7.11.18 skeletal muscle
-
 Meleagris gallopavo
-
2.7.11.18 skeletal muscle
-
 Homo sapiens
-
2.7.11.18 skeletal muscle
-
 Rattus norvegicus
-
2.7.11.18 skeletal muscle
-
 Sus scrofa
-
2.7.11.18 skeletal muscle
-
 Bos taurus
-
2.7.11.18 skeletal muscle back and hindlegs Oryctolagus cuniculus
-
2.7.11.18 smooth muscle
-
 Meleagris gallopavo
-
2.7.11.18 smooth muscle
-
 Homo sapiens
-
2.7.11.18 smooth muscle
-
 Rattus norvegicus
-
2.7.11.18 smooth muscle
-
 Sus scrofa
-
2.7.11.18 smooth muscle
-
 Oryctolagus cuniculus
-
2.7.11.18 smooth muscle arterial Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.18 1.8
-
-
 Bos taurus
2.7.11.18 6
-
-
 Meleagris gallopavo
2.7.11.18 7.9
-
-
 Sus scrofa
2.7.11.18 7.9
-
-
 Bos taurus
2.7.11.18 24
-
 skeletal muscle Oryctolagus cuniculus

Storage Stability

EC Number Storage Stability Organism
2.7.11.18 -20°C, in 5% w/v sucrose, several weeks Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 18.5 kDa Dictyostelium or 19 kDa skeletal muscle light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Meleagris gallopavo ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Sus scrofa ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 Calmodulin requirement Meleagris gallopavo
2.7.11.18 Calmodulin requirement Homo sapiens
2.7.11.18 Calmodulin requirement Rattus norvegicus
2.7.11.18 Calmodulin requirement Sus scrofa
2.7.11.18 Calmodulin requirement Bos taurus
2.7.11.18 Calmodulin requirement Oryctolagus cuniculus
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Meleagris gallopavo
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Homo sapiens
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Rattus norvegicus
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Sus scrofa
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Bos taurus
2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin Oryctolagus cuniculus