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Literature summary extracted from

  • Park, I.; Ives, D.H.
    Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit (2002), J. Biochem. Mol. Biol., 35, 244-247.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.113 D84A 1% of wild-type activity Lactobacillus johnsonii
2.7.1.113 D84E 41% of wild-type activity, not inhibited by dGTP and dATP Lactobacillus johnsonii
2.7.1.113 D84N 5% of wild-type activity Lactobacillus johnsonii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.113 dGTP
-
 Lactobacillus johnsonii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.113 0.087
-
 deoxyguanosine pH 8.0, 20°C Lactobacillus johnsonii
2.7.1.113 0.34
-
 deoxyguanosine pH 8.0, 20°C, D84N mutant enzyme Lactobacillus johnsonii
2.7.1.113 0.36
-
 deoxyguanosine pH 8.0, 20°C, D84A mutant enzyme Lactobacillus johnsonii
2.7.1.113 0.55
-
 deoxyguanosine pH 8.0, 20°C, D84E mutant enzyme Lactobacillus johnsonii

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.113 Lactobacillus johnsonii Q74HC2 strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase
-
2.7.1.113 Lactobacillus johnsonii NCC 533 Q74HC2 strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine
-
 Lactobacillus johnsonii ADP + dGMP
-
 ?
2.7.1.113 ATP + deoxyguanosine
-
 Lactobacillus johnsonii NCC 533 ADP + dGMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.113 deoxyadenosine kinase/deoxyguanosine kinase abbrevation: dAK/dGK Lactobacillus johnsonii