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Literature summary extracted from

  • Kamemoto, E.S.; Iltzsch, M.H.; Lan, L.; Mansour, T.E.
    Phosphofructokinase from Fasciola hepatica: activation by phosphorylation and other regulatory properties distinct from the mammalian enzyme (1987), Arch. Biochem. Biophys., 258, 101-111.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.11 AMP activation Fasciola hepatica
2.7.1.11 AMP one of three most potent activators Fasciola hepatica
2.7.1.11 cAMP-dependent protein kinase activation by phosphorylation Fasciola hepatica
2.7.1.11 cAMP-dependent protein kinase kinetics, one of three most potent activators Fasciola hepatica
2.7.1.11 D-fructose 1,6-bisphosphate activation Fasciola hepatica
2.7.1.11 D-fructose 2,6-bisphosphate activation of native and phosphorylated PFK, one of three most potent activators Fasciola hepatica
2.7.1.11 D-Glucose 1,6-bisphosphate activation Fasciola hepatica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 Aldolase
-
 Fasciola hepatica
2.7.1.11 Aldolase
-
 Ovis aries
2.7.1.11 ATP
-
 Fasciola hepatica
2.7.1.11 ATP
-
 Ovis aries
2.7.1.11 citrate strong inhibition; weak inhibition Fasciola hepatica
2.7.1.11 citrate strong inhibition; weak inhibition Ovis aries
2.7.1.11 phosphatase dephosphorylation inactivates Fasciola hepatica
2.7.1.11 phosphatase dephosphorylation inactivates Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.11 additional information
-
 additional information kinetic study Ovis aries
2.7.1.11 additional information
-
 additional information kinetic study Fasciola hepatica
2.7.1.11 additional information
-
 additional information allosteric kinetics at alkaline pH-values Fasciola hepatica
2.7.1.11 additional information
-
 additional information kinetic properties of phosphorylated enzyme Ovis aries
2.7.1.11 additional information
-
 additional information kinetic properties of phosphorylated enzyme Fasciola hepatica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.11 K+
-
 Fasciola hepatica
2.7.1.11 Mg2+ required for activity Ovis aries
2.7.1.11 Mg2+ required for activity Fasciola hepatica

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Fasciola hepatica
-
-
-
2.7.1.11 Ovis aries
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.11 side-chain modification
-
 Fasciola hepatica

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 brain
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Ovis aries ADP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Fasciola hepatica ADP + D-fructose 1,6-bisphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.11 7
-
 native enzyme Fasciola hepatica
2.7.1.11 7.6
-
 phosphorylated enzyme Fasciola hepatica