BRENDA - Enzyme Database

Zn2+, not Ca2+, is the most effective cation for activation of dolichol kinase of mammalian brain

Sakakihara, Y.; Volpe, J.J.; J. Biol. Chem. 260, 15413-15419 (1985)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.108
additional information
-
Bos taurus
2.7.1.108
additional information
trifluoperazine and chlorpromazine are no inhibitors
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.108
0.075
-
dolichol
pH 7.4, 37C, brain enzyme
Rattus norvegicus
2.7.1.108
1.62
-
CTP
pH 7.4, 37C, brain enzyme
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.108
microsome
-
Bos taurus
-
-
2.7.1.108
microsome
-
Rattus norvegicus
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.108
Ca2+
-
Rattus norvegicus
2.7.1.108
Ca2+
-
Bos taurus
2.7.1.108
Cd2+
slight activation
Rattus norvegicus
2.7.1.108
Co2+
-
Bos taurus
2.7.1.108
Co2+
-
Rattus norvegicus
2.7.1.108
Fe2+
slight activation
Rattus norvegicus
2.7.1.108
Mg2+
-
Bos taurus
2.7.1.108
Mg2+
-
Rattus norvegicus
2.7.1.108
additional information
-
Bos taurus
2.7.1.108
additional information
not activated by Cu2+
Rattus norvegicus
2.7.1.108
Ni2+
slight activation
Rattus norvegicus
2.7.1.108
Sr2+
slight activation
Rattus norvegicus
2.7.1.108
Zn2+
-
Bos taurus
2.7.1.108
Zn2+
most effective cation for activation of brain enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.108
CTP + dolichol
Rattus norvegicus
-
CDP + dolichyl phosphate
-
Rattus norvegicus
?
2.7.1.108
CTP + dolichol
Bos taurus
-
CDP + dolichyl phosphate
-
Bos taurus
?
2.7.1.108
CTP + dolichol
Rattus norvegicus Sprague-Dawley
-
CDP + dolichyl phosphate
-
Rattus norvegicus Sprague-Dawley
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.108
Bos taurus
-
calf
-
2.7.1.108
Rattus norvegicus
-
cultured C-6 glial cells; Sprague-Dawley
-
2.7.1.108
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.108
brain
-
Rattus norvegicus
-
2.7.1.108
brain
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.108
CTP + dolichol
-
640395
Rattus norvegicus
CDP + dolichyl phosphate
-
640395
Rattus norvegicus
?
2.7.1.108
CTP + dolichol
-
640395
Bos taurus
CDP + dolichyl phosphate
-
640395
Bos taurus
?
2.7.1.108
CTP + dolichol
-
640395
Rattus norvegicus Sprague-Dawley
CDP + dolichyl phosphate
-
640395
Rattus norvegicus Sprague-Dawley
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.108
additional information
-
Bos taurus
2.7.1.108
additional information
trifluoperazine and chlorpromazine are no inhibitors
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.108
0.075
-
dolichol
pH 7.4, 37C, brain enzyme
Rattus norvegicus
2.7.1.108
1.62
-
CTP
pH 7.4, 37C, brain enzyme
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.108
microsome
-
Bos taurus
-
-
2.7.1.108
microsome
-
Rattus norvegicus
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.108
Ca2+
-
Rattus norvegicus
2.7.1.108
Ca2+
-
Bos taurus
2.7.1.108
Cd2+
slight activation
Rattus norvegicus
2.7.1.108
Co2+
-
Bos taurus
2.7.1.108
Co2+
-
Rattus norvegicus
2.7.1.108
Fe2+
slight activation
Rattus norvegicus
2.7.1.108
Mg2+
-
Bos taurus
2.7.1.108
Mg2+
-
Rattus norvegicus
2.7.1.108
additional information
-
Bos taurus
2.7.1.108
additional information
not activated by Cu2+
Rattus norvegicus
2.7.1.108
Ni2+
slight activation
Rattus norvegicus
2.7.1.108
Sr2+
slight activation
Rattus norvegicus
2.7.1.108
Zn2+
-
Bos taurus
2.7.1.108
Zn2+
most effective cation for activation of brain enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.108
CTP + dolichol
Rattus norvegicus
-
CDP + dolichyl phosphate
-
Rattus norvegicus
?
2.7.1.108
CTP + dolichol
Bos taurus
-
CDP + dolichyl phosphate
-
Bos taurus
?
2.7.1.108
CTP + dolichol
Rattus norvegicus Sprague-Dawley
-
CDP + dolichyl phosphate
-
Rattus norvegicus Sprague-Dawley
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.108
brain
-
Rattus norvegicus
-
2.7.1.108
brain
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.108
CTP + dolichol
-
640395
Rattus norvegicus
CDP + dolichyl phosphate
-
640395
Rattus norvegicus
?
2.7.1.108
CTP + dolichol
-
640395
Bos taurus
CDP + dolichyl phosphate
-
640395
Bos taurus
?
2.7.1.108
CTP + dolichol
-
640395
Rattus norvegicus Sprague-Dawley
CDP + dolichyl phosphate
-
640395
Rattus norvegicus Sprague-Dawley
?