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Literature summary extracted from

  • Sakane, F.; Kanoh, H.
    Molecules in focus: diacylglycerol kinase (1997), Int. J. Biochem. Cell Biol., 29, 1139-1143.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.107 Ca2+ plus phosphatidylserine, activates enzyme DGK-Igamma Homo sapiens
2.7.1.107 Ca2+ plus phosphatidylserine, activates enzyme DGK-Ibeta Rattus norvegicus
2.7.1.107 Ca2+ plus phosphatidylserine, activates enzyme DGK-Ialpha Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.107 82200
-
 x * 82200, DGK-Ialpha, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 82600
-
 x * 82600, DGK-Ialpha, calculation from amino acid sequence Sus scrofa
2.7.1.107 82700
-
 x * 82700, DGK-Ialpha, calculation from amino acid sequence Homo sapiens
2.7.1.107 88500
-
 x * 88500, DGK-Igamma, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 89000
-
 x * 89000, DGK-Igamma, calculation from amino acid sequence Homo sapiens
2.7.1.107 90300
-
 x * 90300, DGK-Ibeta, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 101400
-
 x * 101400, DGK-Vtheta, calculation from amino acid sequence Homo sapiens
2.7.1.107 104000
-
 x * 104000, DGK-IVksi, calculation from amino acid sequence Homo sapiens
2.7.1.107 104000
-
 x * 104000, DGK-IVksi, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 126800
-
 x * 126800, DGK-IIeta, calculation from amino acid sequence Mesocricetus auratus
2.7.1.107 130000
-
 x * 130000, DGK-IIdelta, calculation from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Rattus norvegicus
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Mesocricetus auratus
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Sus scrofa DGK-Ialpha is involved in IL-2-mediated lymphocyte proliferation ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens
-
-
-
2.7.1.107 Mesocricetus auratus
-
-
-
2.7.1.107 Rattus norvegicus
-
-
-
2.7.1.107 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 adrenal gland DGK-Ibeta Rattus norvegicus
-
2.7.1.107 brain
-
 Sus scrofa
-
2.7.1.107 brain Purkinje cells, DGK-Igamma Rattus norvegicus
-
2.7.1.107 brain DGK-Vtheta, cerebellar cortex and hippocampus Homo sapiens
-
2.7.1.107 brain DGK-IIeta Mesocricetus auratus
-
2.7.1.107 brain neuron, DGK-Ibeta Rattus norvegicus
-
2.7.1.107 brain DGK-Ialpha Homo sapiens
-
2.7.1.107 brain DGK-IVksi Rattus norvegicus
-
2.7.1.107 brain oligodendrocyte, DGK-Ialpha Rattus norvegicus
-
2.7.1.107 cerebellar Purkinje cell DGK-Igamma Rattus norvegicus
-
2.7.1.107 Hep-G2 cell DGK-IIdelta Homo sapiens
-
2.7.1.107 lung
-
 Rattus norvegicus
-
2.7.1.107 lung DGK-IIeta Mesocricetus auratus
-
2.7.1.107 neuron of the brain, DGK-Ibeta Rattus norvegicus
-
2.7.1.107 oligodendrocyte of the brain, DGK-Ialpha Rattus norvegicus
-
2.7.1.107 retina DGK-Igamma Homo sapiens
-
2.7.1.107 skeletal muscle DGK-IVksi Homo sapiens
-
2.7.1.107 skeletal muscle DGK-IVksi Rattus norvegicus
-
2.7.1.107 skeletal muscle DGK-IIdelta Homo sapiens
-
2.7.1.107 T-lymphocyte
-
 Homo sapiens
-
2.7.1.107 T-lymphocyte
-
 Rattus norvegicus
-
2.7.1.107 T-lymphocyte DGK-Ialpha Sus scrofa
-
2.7.1.107 testis DGK-IIeta Mesocricetus auratus
-
2.7.1.107 testis DGK-IIdelta and DGK-IIIepsilon Homo sapiens
-
2.7.1.107 thymus
-
 Rattus norvegicus
-
2.7.1.107 thymus DGK-IVksi Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Rattus norvegicus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Mesocricetus auratus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol DGK-Ialpha is involved in IL-2-mediated lymphocyte proliferation Sus scrofa ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.107 ? x * 104000, DGK-IVksi, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 104000, DGK-IVksi, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 ? x * 101400, DGK-Vtheta, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 130000, DGK-IIdelta, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 90300, DGK-Ibeta, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 ? x * 89000, DGK-Igamma, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 82700, DGK-Ialpha, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 126800, DGK-IIeta, calculation from amino acid sequence Mesocricetus auratus
2.7.1.107 ? x * 88500, DGK-Igamma, calculation from amino acid sequence Rattus norvegicus
2.7.1.107 ? x *63900, DGK-IIIepsilon, calculation from amino acid sequence Homo sapiens
2.7.1.107 ? x * 82600, DGK-Ialpha, calculation from amino acid sequence Sus scrofa
2.7.1.107 ? x * 82200, DGK-Ialpha, calculation from amino acid sequence Rattus norvegicus