EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | R59949 | DGKalpha | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | Mus musculus | high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.107 | Mus musculus | - |
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- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.107 | brain | DGKalpha | Mus musculus | - |
2.7.1.107 | T-cell | DGKalpha | Mus musculus | - |
2.7.1.107 | thymocyte | DGKalpha | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway | Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
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