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Literature summary extracted from

  • Yamada, K.; Sakane, F.; Imai, S.; Tsushima, S.; Murakami, T.; Kanoh, H.
    Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells (2003), Biochem. Biophys. Res. Commun., 305, 101-107.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytoplasm prior to cell attachment, phorbol ester induce translocation of DGKgamma from the cytoplasm to the cell periphery Homo sapiens 5737
-
2.7.1.107 extracellular prior to cell attachment, phorbol ester induce translocation of DGKgamma from the cytoplasm to the cell periphery Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Homo sapiens DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens
-
-
-
2.7.1.107 Homo sapiens
-
 DGKgamma
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 granulocyte enzyme expression remains almost unchanged in granulocytic differentiation pathway Homo sapiens
-
2.7.1.107 granulocyte enzyme expression remained almost unchanged in granulocytic differentiation pathway Homo sapiens
-
2.7.1.107 HL-60 cell level of DGKgamma is rapidly and markedly decreased upon cellular differentiation into macrophages Homo sapiens
-
2.7.1.107 HL-60 cell levels of DGKgamma mRNA/protein is rapidly and markedly decreased upon cellular differentiation into macrophages Homo sapiens
-
2.7.1.107 U-937 cell levels of DGKgamma mRNA/protein is rapidly and markedly decreased upon cellular differentiation into macrophages Homo sapiens
-
2.7.1.107 U937 cell level of DGKgamma is rapidly and markedly decreased upon cellular differentiation into macrophages Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKgamma
-
 Homo sapiens