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Literature summary extracted from

  • Van Schaftingen, E.; Hers, H.G.
    Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP (1981), Biochem. Biophys. Res. Commun., 101, 1078-1084.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.105 citrate
-
 Rattus norvegicus
2.7.1.105 phosphoenolpyruvate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.105 0.4
-
 beta-D-fructose 6-phosphate pH 7.1, 37°C Rattus norvegicus
2.7.1.105 0.5
-
 MgATP2-
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.105 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.105 Mg2+ MgATP2 Rattus norvegicus
2.7.1.105 phosphate activation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.105 phosphoprotein phophorylation by cAMP-dependent protein kinase causes activation Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.105 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 hepatocyte
-
 Rattus norvegicus
-
2.7.1.105 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.105 additional information
-
-
 Rattus norvegicus
2.7.1.105 0.0076
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate transfers gamma-phosphoryl group of ATP to hydroxyl group at C-2 of fructose 6-phosphate Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 MgATP2- + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.105 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.105 AMP
-
 Rattus norvegicus