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Literature summary extracted from

  • Lai, J.C.K.; Behar, K.L.; Liang, B.B.; Hertz, L.
    Hexokinase in astrocytes: Kinetic and regulatory properties (1999), Metab. Brain Dis., 14, 125-133.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 D-glucose 1,6-diphosphate at concentrations higher than 0.2 mM, inhibits in a concentration-dependent manner, 1.2 mM: almost complete inhibition Mus musculus
2.7.1.1 glucose 1,6-disphosphate
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.208
-
 ATP MgATP2- Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.1 Mg2+ absolute requirement for MgATP2- and Mg2+ Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 D-glucose + ATP Mus musculus key enzyme in the control of brain glucose metabolism D-glucose 6-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Mus musculus
-
 newborn mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 astrocyte cerebrocortical astrocytes in primary culture, prepared from the neopallium Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.1 additional information
-
-
 Mus musculus
2.7.1.1 0.033 0.04
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-glucose + ATP absolute requirement for D-glucose Mus musculus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP key enzyme in the control of brain glucose metabolism Mus musculus D-glucose 6-phosphate + ADP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.1 7.4 8
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.1 5.6 9.2 at pH 5.6: 70% of maximum activity, at pH 9.2: 50% of maximum activity Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP absolute requirement for MgATP2- Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.4
-
 glucose 1,6-disphosphate IC50 Mus musculus