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Literature summary extracted from

  • Magnani, M.; Stocchi, V.; Serafini, N.; Piatti, E.; Dacha, M.; Fornaini, G.
    Pig red blood cell hexokinase: Regulatory characteristics and possible physiological role (1983), Arch. Biochem. Biophys., 226, 377-387.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 2,3-diphosphoglycerate hexokinase III Sus scrofa
2.7.1.1 2-phosphoglycerate hexokinase III Sus scrofa
2.7.1.1 3-phosphoglycerate hexokinase III Sus scrofa
2.7.1.1 ADP hexokinase III Sus scrofa
2.7.1.1 ATP ATP4-; hexokinase III; uncomplexed, competitive to MgATP2-, erythrocyte enzyme Sus scrofa
2.7.1.1 D-fructose 1,6-diphosphate hexokinase III Sus scrofa
2.7.1.1 D-fructose 6-phosphate hexokinase III Sus scrofa
2.7.1.1 D-glucose higher than 0.4 mM; inhibits hexokinase III Sus scrofa
2.7.1.1 D-glucose 1,6-diphosphate hexokinase III Sus scrofa
2.7.1.1 D-glucose 6-phosphate hexokinase III, poor inhibitor, not relieved by phosphate Sus scrofa
2.7.1.1 dihydroxyacetonephosphate hexokinase III Sus scrofa
2.7.1.1 Mg2+ competitive to MgATP2-; uncomplexed Sus scrofa
2.7.1.1 additional information not inhibited by glyceraldehyde 3-phosphate, pyruvate, lactate Sus scrofa
2.7.1.1 phosphate hexokinase III Sus scrofa
2.7.1.1 phosphoenolpyruvate hexokinase III Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.5
-
ATP hexokinase III, at 30°C, pH 8.1 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 D-glucose + ATP Sus scrofa the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose D-glucose 6-phosphate + ADP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Sus scrofa
-
2 enzyme forms: hexokinase type II and type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 erythrocyte hexokinase types II and III, hexokinase III is the predominant form in adult pig erythrocytes, hexokinase II in newborn pig erythrocytes Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-glucose + ATP
-
Sus scrofa ADP + D-glucose 6-phosphate
-
?
2.7.1.1 D-glucose + ATP the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose Sus scrofa D-glucose 6-phosphate + ADP
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.1 30
-
assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.1 7.2
-
assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.04
-
D-glucose 1,6-diphosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 0.12
-
D-glucose 6-phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 0.5
-
ADP hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 0.5
-
D-fructose 6-phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 0.5
-
ATP uncomplexed ATP4-, hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 2.5
-
D-fructose 1,6-diphosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 2.5
-
dihydroxyacetonephosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 5
-
2,3-diphosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 7.8
-
phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 8
-
phosphoenolpyruvate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 12
-
3-phosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 13
-
2-phosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.7.1.1 30
-
Mg2+ uncomplexed, hexokinase III, at 30°C, pH 7.2 Sus scrofa