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Literature summary extracted from

  • Schadewaldt, P.; Adelmeyer, F.
    Coupled enzymatic assay for estimation of branched-chain L-amino acid aminotransferase activity with 2-Oxo acid substrates (1996), Anal. Biochem., 238, 65-71.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.42 4-methyl-2-oxopentanoate
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.42 0.07
-
(R,S)-3-methyl-2-oxopentanoate pH 8.3, 25°C Rattus norvegicus
2.6.1.42 0.11
-
3-methyl-2-oxobutanoate pH 8.3, 25°C Rattus norvegicus
2.6.1.42 0.14
-
4-methyl-2-oxopentanoate pH 8.3, 25°C Rattus norvegicus
2.6.1.42 2.45
-
L-glutamate pH 8.3, 25°C, (R,S)-3-methyl-2-oxopentanoate as amino group acceptor Rattus norvegicus
2.6.1.42 3.6
-
L-glutamate pH 8.3, 25°C, 3-methyl-2-oxobutanoate as amino group acceptor Rattus norvegicus
2.6.1.42 6.65
-
L-glutamate pH 8.3, 25°C, 4-methyl-2-oxopentanoate as amino group acceptor Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.42 L-leucine + 2-oxoglutarate Rattus norvegicus
-
4-methyl-2-oxopentanoate + L-glutamate
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.42 Bos taurus
-
bovine
-
2.6.1.42 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.42 partially Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.42 aorta endothelial cells Bos taurus
-
2.6.1.42 heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.42 L-leucine + 2-oxoglutarate
-
Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
r
2.6.1.42 L-leucine + 4-methyl-2-oxopentanoate
-
Rattus norvegicus 4-methyl-2-oxopentanoate + L-leucine
-
r

Synonyms

EC Number Synonyms Comment Organism
2.6.1.42 BCAA-AT
-
Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.42 8.2
-
-
Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.42 7 9
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.42 2.1
-
4-methyl-2-oxopentanoate pH 8.3, 25°C Rattus norvegicus