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Literature summary extracted from

  • Mori, Y.; Nishikawa, M.; Toyoda, N.; Yonemoto, T.; Matsubara, H.; Inada, M.
    Iodothyronine 5'-deiodinase activity in cultured rat myocardial cells: characteristics and effects of triiodothyronine and angiotensin II (1991), Endocrinology, 128, 3105-3112.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 dithiothreitol high concentrations of cofactor increases type I activity Rattus sp.
1.21.99.4 additional information no effect of insulin and dexamethasone on type I activity Rattus sp.
1.21.99.4 reduced thiols e.g. dithiothreitol Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
1.21.99.4 additional information 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.065
-
 3,3',5'-triiodothyronine DTT 10 mM Rattus sp.
1.21.99.4 0.065
-
 3,3',5'-triiodothyronine type I, myocardial Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp.
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Rattus sp.
-
 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 myocardium thyronine 5'-deiodinase type I Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2
-
 Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) Rattus sp.

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.21.99.4 4
-
 inactivation after 30 min Rattus sp.
1.21.99.4 56
-
 inactivation after 30 min Rattus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.4 7 7.4
-
 Rattus sp.