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Literature summary extracted from

  • Leonard, J.L.; Siegrist-Kaiser, C.A.; Zuckerman, C.J.
    Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone (1990), J. Biol. Chem., 265, 940-946.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 thyroid hormone L-thyroxine and 3,3',5'-triiodothyronine extra-nuclear site of action Rattus sp.

General Stability

EC Number General Stability Organism
1.21.99.4 very short lifetime in vivo of isoenzyme type II (D2) from brain Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 Insulin inhibits enzyme expression in glial cell culture Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.4 membrane bound, type II integral in neurolemmal membranes Rattus sp. 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Rattus sp.
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 glial cell i.e. brain astrocytes in culture Rattus sp.
-
1.21.99.4 glial cell measurable activity only during induction with bt2cAMP Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.21.99.4 0.000467
-
 3,3',5'-triiodothyronine
-
 Rattus sp.
1.21.99.4 0.00107
-
 3,3',5'-triiodothyronine in hypothyroid medium Rattus sp.