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Literature summary extracted from

  • Wiebe, J.P.; Boushy, D.; Wolfe, M.
    Synthesis, metabolism and levels of the neuroactive steroid, 3alpha-hydroxy-4-pregnen-20-one (3alphaHP), in rat pituitaries (1997), Brain Res., 764, 158-166.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.278 5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus low activity 3beta-hydroxy-5alpha-pregnane-20-one + NADP+
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 r
1.1.1.278 5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus biosynthetic pathway, overview 3beta-hydroxy-5alpha-pregnane-20-one + NADP+
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 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.278 Rattus norvegicus
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 female Sprague-Dawley rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.278 pituitary gland anterior, low activity Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.278 5alpha-pregnan-3,20-dione + NAD(P)H low activity Rattus norvegicus 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ i.e. 5alpha-pregnan-3beta-ol-20-one r
1.1.1.278 5alpha-pregnan-3,20-dione + NADPH low activity Rattus norvegicus 3beta-hydroxy-5alpha-pregnane-20-one + NADP+
-
 r
1.1.1.278 5alpha-pregnan-3,20-dione + NADPH biosynthetic pathway, overview Rattus norvegicus 3beta-hydroxy-5alpha-pregnane-20-one + NADP+
-
 r