EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.21 | Fe2+ | required | Streptomyces clavuligerus | |
1.14.11.21 | Fe2+ | conformation during catalytic reaction | Streptomyces clavuligerus | |
1.14.11.21 | Fe2+ | isozyme CS2, five and six-coordinate ferrous species in the enzyme-substrate complexes, structural model of conversion for the different reactions | Streptomyces clavuligerus | |
1.14.11.21 | Fe2+ | no ligand switching among the histidine residues of the protein | Streptomyces clavuligerus | |
1.14.11.21 | Fe2+ | isozyme CS2, a single ferrous active site | Streptomyces clavuligerus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.3.3.4 | 54500 | - |
x * 54500, deduced from gene sequence | Streptomyces clavuligerus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.21 | deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | dihydroclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
clavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | additional information | Streptomyces clavuligerus | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | ? | - |
? | |
1.14.11.21 | proclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
6.3.3.4 | N2-(carboxyethyl)-L-arginine + ATP | Streptomyces clavuligerus | overview on biological role | AMP + diphosphate + deoxyamidinoproclavaminate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.21 | Streptomyces clavuligerus | - |
2 isozymes CS1 and CS2 | - |
1.14.11.21 | Streptomyces clavuligerus | - |
isozyme CS2 is encoded on orf5 | - |
6.3.3.4 | Streptomyces clavuligerus | P0DJQ7 | - |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.14.11.21 | deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 | this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla | Streptomyces clavuligerus | |
6.3.3.4 | ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate | overview | Streptomyces clavuligerus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.21 | deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | Streptomyces clavuligerus | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | hydroxylation | Streptomyces clavuligerus | guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | dihydroclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | dihydroclavaminate + 2-oxoglutarate + O2 | cyclization | Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | additional information | specific for 2-oxoglutarate | Streptomyces clavuligerus | ? | - |
? | |
1.14.11.21 | additional information | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | Streptomyces clavuligerus | ? | - |
? | |
1.14.11.21 | proclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
1.14.11.21 | proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
6.3.3.4 | N2-(carboxyethyl)-L-arginine + ATP | overview on biological role | Streptomyces clavuligerus | AMP + diphosphate + deoxyamidinoproclavaminate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
6.3.3.4 | ? | x * 54500, deduced from gene sequence | Streptomyces clavuligerus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.3.4 | ATP | ATP-binding site | Streptomyces clavuligerus |