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Literature summary extracted from
- Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha (2002), Biochemistry, 41, 4972-4981.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | phorbol ester | - |
Mus musculus |  |
| 3.4.24.86 | phorbol ester | - |
Homo sapiens | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | - |
Mus musculus |
| 3.4.24.86 | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | Hydroxamate | - |
Chlorocebus aethiops | |
| 3.4.24.86 | Hydroxamate | - |
Homo sapiens | |
| 3.4.24.86 | Hydroxamate | - |
Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Chlorocebus aethiops | - |
african green monkey, COS-7, an SV40 transformed kidney cell line | - |
| 3.4.24.86 | Homo sapiens | - |
SH-SY5Y | - |
| 3.4.24.86 | Homo sapiens | - |
human monocytic cell line THP-1 | - |
| 3.4.24.86 | Homo sapiens | - |
HEK293 cells | - |
| 3.4.24.86 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | blood | - |
Mus musculus | - |
| 3.4.24.86 | blood | - |
Homo sapiens | - |
| 3.4.24.86 | embryo | - |
Mus musculus | - |
| 3.4.24.86 | embryo | - |
Homo sapiens | - |
| 3.4.24.86 | fibroblast | - |
Mus musculus | - |
| 3.4.24.86 | fibroblast | - |
Homo sapiens | - |
| 3.4.24.86 | kidney | - |
Mus musculus | - |
| 3.4.24.86 | kidney | - |
Homo sapiens | - |
| 3.4.24.86 | kidney | - |
Chlorocebus aethiops | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.86 | beta-amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | beta-amyloid precursor protein + H2O | Alzheimer amyloid precursor protein | Homo sapiens | ? | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Chlorocebus aethiops | ? | - |
? | |
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Release 2023.1 (January 2023)
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