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Literature summary extracted from

  • Mohan, M.J.; Seaton, T.; Mitchell, J.; Howe, A.; Blackburn, K.; Burkhart, W.; Moyer, M.; Patel, I.; Waitt, G.M.; Becherer, J.D.; Moss, M.L.; Milla, M.E.
    The tumor necrosis factor-alpha converting enzyme (TACE): A unique metalloproteinase with highly defined substrate selectivity (2002), Biochemistry, 41, 9462-9469.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.86 medicine targeting this key enzyme for therapeutic intervention in inflammatory diseases, cancer and AIDS Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 membrane
-
 Mus musculus 16020
-
3.4.24.86 membrane
-
 Homo sapiens 16020
-
3.4.24.86 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.86 Zn2+
-
 Mus musculus
3.4.24.86 Zn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
 MonoMac 6 cells
-
3.4.24.86 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.86
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 75kDaTNFR2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 beta-amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 beta-amyloid precursor protein + H2O Alzheimer amyloid precursor protein Homo sapiens ?
-
 ?
3.4.24.86 beta-amyloid precursor protein + H2O APP Homo sapiens ?
-
 ?
3.4.24.86 c-KLR + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 CD30 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 cellular prion protein PrPc + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 fractalkine + H2O FK, CX3CL1 Homo sapiens ?
-
 ?
3.4.24.86 GHR + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 interleukin-6-receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 KL-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 L-selectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 L-selectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 macrophage colony-stimulating factor receptor M-CSFR + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 additional information
-
 Mus musculus ?
-
 ?
3.4.24.86 additional information 4-dinitrophenyl)-L-2,3-diaminopropionyl diaminopropionic amide-PChaGC(Me)HK(NMA)-NH2 is not cleaved at all by TACE Homo sapiens ?
-
 ?
3.4.24.86 notch 1 receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 p55 TNFR1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 p55 TNFR1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 RANKL + ?
-
 Homo sapiens ?
-
 ?
3.4.24.86 TRANCE + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?