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Literature summary extracted from
- Tumor necrosis factor-alpha converting enzyme (2002), Int. J. Biochem. Cell Biol., 34, 1-5.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | phorbol ester | - |
Mus musculus |  |
| 3.4.24.86 | phorbol ester | - |
Homo sapiens | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.86 | medicine | pharmaceutical industry is attempting to design specific TACE inhibitors to treat inflammatory diseases, may also be beneficial in treating certain cancers | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | - |
Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | - |
Homo sapiens |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.4.24.86 | in absence of cell activators the enzyme is long-lived, with a half-life of more than 8h | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | peptide hydroxamate | - |
Homo sapiens | |
| 3.4.24.86 | TIMP-3 | tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.86 | cell surface | - |
Mus musculus | 9986 | - |
| 3.4.24.86 | cell surface | - |
Homo sapiens | 9986 | - |
| 3.4.24.86 | cytoplasm | - |
Mus musculus | 5737 | - |
| 3.4.24.86 | cytoplasm | - |
Homo sapiens | 5737 | - |
| 3.4.24.86 | Golgi apparatus | - |
Mus musculus | 5794 | - |
| 3.4.24.86 | Golgi apparatus | - |
Homo sapiens | 5794 | - |
| 3.4.24.86 | membrane | membrane-bound | Mus musculus | 16020 | - |
| 3.4.24.86 | membrane | membrane-bound | Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | Zn2+ | - |
Mus musculus | |
| 3.4.24.86 | Zn2+ | zinc-dependent catalytic domain | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Homo sapiens | - |
HUVECs | - |
| 3.4.24.86 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | embryo | - |
Mus musculus | - |
| 3.4.24.86 | embryo | - |
Homo sapiens | - |
| 3.4.24.86 | fibroblast | - |
Mus musculus | - |
| 3.4.24.86 | fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.86 | beta-amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | beta-amyloid precursor protein + H2O | Alzheimer amyloid precursor protein | Homo sapiens | ? | - |
? | |
| 3.4.24.86 | interleukin (IL)-1R-II + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | interleukin (IL)-1R-II + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.86 | p55 TNFR1 + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | p55 TNFR1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.86 | (TACE/ADAM17/CD156q) | - |
Homo sapiens |
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