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Literature summary extracted from

  • Garton, K.J.; Gough, P.J.; Blobel, C.P.; Murphy, G.; Greaves, D.R.; Dempsey, P.J.; Raines, E.W.
    Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) (2001), J. Biol. Chem., 276, 37993-38001.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 cloned with retroviral expression plasmids Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 membrane membrane-bound Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 endothelium
-
 Homo sapiens
-
3.4.24.86 fibroblast dermal fibroblasts Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 fractalkine + H2O FK, CX3CL1 Homo sapiens ?
-
 ?
3.4.24.86 interleukin-6-receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 (TACE:ADAM17)
-
 Homo sapiens