Literature summary extracted from

Moss, M.; Becherer, J.D.; Milla, M.; Pahel, G.; Lambert, M.; Andrews, R.; Frye, S.; Haffner, C.; Cowan, D.; Maloney, P.; Dixon, E.P.; Jansen, M.; Vitek, M.P.; Mitchell, J.; Leesnitzer, T.; Warner, J.; Conway, J.; Bickett, D.M.; Bird, M.; Priest, R.; Reinhard, J.; Lin, P.
TNF.alpha. converting enzyme (1999), Metalloproteinases as targets for anti-inflammatory drugs, (Bottomley, K. M. K; Bradshaw, D. ; Nixon, J. S. eds. ), , 187-203.

No PubMed abstract available

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.86	cDNA encoding TACE, full-length human TACE, inefficiently expressed in insect cells, baculovirus particles in Sf9 cell line from Spodoptera frugiperda	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.86	GW1988	-	Homo sapiens
3.4.24.86	GW9471	-	Homo sapiens
3.4.24.86	GW9471	-	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.24.86	cytoplasm	cytoplasmic tail	Mus musculus	5737	-
3.4.24.86	cytoplasm	cytoplasmic tail	Homo sapiens	5737	-
3.4.24.86	membrane	-	Mus musculus	16020	-
3.4.24.86	membrane	microsomal membrane, transmembrane domain	Homo sapiens	16020	-

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.24.86	Zn2+	zinc metalloprotease	Mus musculus
3.4.24.86	Zn2+	zinc metalloprotease	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.24.86	80000	100000	sucrose density gradient centrifugation	Mus musculus
3.4.24.86	85000	-	glycerol gradient, gel filtration	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.86	Homo sapiens	-	human	-
3.4.24.86	Homo sapiens	-	MonoMac 6 cells	-
3.4.24.86	Mus musculus	-	-	-
3.4.24.86	Mus musculus	-	mouse	-
3.4.24.86	Mus musculus C3H/HEN	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.24.86	-	Mus musculus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.86	monocyte	-	Mus musculus	-
3.4.24.86	monocyte	-	Homo sapiens	-
3.4.24.86	spleen	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.86	proTNF-alpha + H2O	-	Mus musculus	soluble TNF-alpha	-	?
3.4.24.86	proTNF-alpha + H2O	-	Homo sapiens	soluble TNF-alpha	-	?
3.4.24.86	proTNF-alpha + H2O	-	Mus musculus C3H/HEN	soluble TNF-alpha	-	?
3.4.24.86	transforming growth factor alpha + H2O	-	Mus musculus	?	-	?
3.4.24.86	transforming growth factor alpha + H2O	-	Homo sapiens	?	-	?
3.4.24.86	transforming growth factor alpha + H2O	-	Mus musculus C3H/HEN	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.86	H-TACE	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)