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Literature summary extracted from
- Characterization of the tumor necrosis factor alpha-converting enzyme, TACE/ADAM17 (1999), Biochem. Soc. Trans., 27, 219-223.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.86 | medicine | isolation of TACE facilitates the development of therapeutically useful inhibitors of TNF-alpha release | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | isolation of cDNA clones encoding TACE by PCR | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | EDTA | - |
Homo sapiens |  |
| 3.4.24.86 | TAPI | hydroxamic acid-based broad-spectrum inhibitor of zinc metalloproteinases | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.86 | 85000 | - |
SDS-PAGE | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Homo sapiens | - |
human | - |
| 3.4.24.86 | Homo sapiens | - |
human monocytic cell line THP-1 | - |
| 3.4.24.86 | Mus musculus | - |
mouse | - |
| 3.4.24.86 | Mus musculus | - |
strain 129, strain C57Bl/6 chimaera/ly9.l- | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | blood | peripheral blood T-cells | Mus musculus | - |
| 3.4.24.86 | blood | peripheral blood T-cells | Homo sapiens | - |
| 3.4.24.86 | bone marrow | - |
Mus musculus | - |
| 3.4.24.86 | bone marrow | - |
Homo sapiens | - |
| 3.4.24.86 | brain | - |
Homo sapiens | - |
| 3.4.24.86 | brain | fetal brain | Mus musculus | - |
| 3.4.24.86 | endothelium | - |
Mus musculus | - |
| 3.4.24.86 | endothelium | - |
Homo sapiens | - |
| 3.4.24.86 | heart | - |
Mus musculus | - |
| 3.4.24.86 | kidney | - |
Mus musculus | - |
| 3.4.24.86 | kidney | - |
Homo sapiens | - |
| 3.4.24.86 | liver | - |
Mus musculus | - |
| 3.4.24.86 | lung | - |
Mus musculus | - |
| 3.4.24.86 | lung | - |
Homo sapiens | - |
| 3.4.24.86 | monocyte | - |
Mus musculus | - |
| 3.4.24.86 | monocyte | - |
Homo sapiens | - |
| 3.4.24.86 | muscle | - |
Homo sapiens | - |
| 3.4.24.86 | muscle | skeletal muscle, smooth muscle cells | Mus musculus | - |
| 3.4.24.86 | neutrophil | - |
Mus musculus | - |
| 3.4.24.86 | ovary | - |
Mus musculus | - |
| 3.4.24.86 | pancreas | - |
Mus musculus | - |
| 3.4.24.86 | placenta | - |
Mus musculus | - |
| 3.4.24.86 | prostate | - |
Mus musculus | - |
| 3.4.24.86 | small intestine | - |
Mus musculus | - |
| 3.4.24.86 | spleen | - |
Mus musculus | - |
| 3.4.24.86 | testis | - |
Mus musculus | - |
| 3.4.24.86 | thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.86 | proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | release of membrane-bound TNF-alpha | ? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
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