EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.22.49 | C2029A | no autoproteolytic cleavage, unable to cleave SCC1 | Homo sapiens |
3.4.22.49 | S1126A | cleaved autoproteolytically to the same degree as wild-type, shows similar SCC1 cleavage activity as wild-type | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.49 | peptide | acyloxymethyl ketone derivative of human SCC1 cleavage site peptide, chloromethyl ketone derivatives of the yeast Scc1 cleavage site | Homo sapiens | |
3.4.22.49 | securin | securin inhibits separase by blocking the access of substrates to the active site | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.49 | cohesin + H2O | Homo sapiens | separase is required for sister chromatid separation during mitosis | cleaved cohesin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.49 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.49 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.49 | cohesin + H2O | separase is required for sister chromatid separation during mitosis | Homo sapiens | cleaved cohesin | - |
? |