EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.149 | ATP | omitting ATP from reaction mixture decreases activity by 87% | Homo sapiens | |
2.4.1.149 | additional information | not activated by Triton X-100 | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.149 | 0.133 | - |
UDP-N-acetyl-D-glucosamine | lactose as acceptor | Homo sapiens | |
2.4.1.149 | 7 | - |
N-acetyllactosamine | - |
Homo sapiens | |
2.4.1.149 | 29.8 | - |
lactose | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.149 | soluble | - |
Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.149 | Mn2+ | essential for activity, neither Mg2+ nor Ca2+ can substitute for Mn2+ | Homo sapiens | |
2.4.1.149 | additional information | not activated by Mg2+ or Ca2+ | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.149 | UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | Homo sapiens | involved in the biosynthesis of blood group precursors, enzyme might control the biosynthesis of the linear carbohydrate chain by adding a N-acetylglucosaminyl residue to a Galbeta(1-4)GlcNAc-R structure present on oligosaccharides, glycosylceramides and glycoproteins | UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.149 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.149 | serum | normal blood group 0 serum | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.149 | additional information | no acceptors: melibiose, gentiobiose, galactose, glucose, N-acetylgalactosamine, N-acetylglucosamine | Homo sapiens | ? | - |
? | |
2.4.1.149 | UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
Homo sapiens | UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
? | |
2.4.1.149 | UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | involved in the biosynthesis of blood group precursors, enzyme might control the biosynthesis of the linear carbohydrate chain by adding a N-acetylglucosaminyl residue to a Galbeta(1-4)GlcNAc-R structure present on oligosaccharides, glycosylceramides and glycoproteins | Homo sapiens | UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
? | |
2.4.1.149 | UDP-N-acetylglucosamine + lactose | less effective acceptor than N-acetyllactosamine | Homo sapiens | UDP + GlcNAcbeta(1-3)Galbeta(1-4)Glc | - |
? | |
2.4.1.149 | UDP-N-acetylglucosamine + N-acetyllactosamine | more effective acceptor than lactose | Homo sapiens | UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.149 | 37 | - |
assay at | Homo sapiens |