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Literature summary extracted from

  • Zielenski, J.; Koscielak, J.
    The occurrence of two novel N-acetylglucosaminyltransferase activities in human serum (1983), FEBS Lett., 158, 164-168.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.149 Mn2+ requirement Homo sapiens
2.4.1.150 Mn2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.149 additional information Homo sapiens the enzyme together with N-acetyllactosamine synthase, EC 2.4.1.90, catalyzes formation of linear glycans containing alternating beta-3-O-substituted residues of D-galactose and beta-4-O-substituted residues of N-acetyl-D-glucosamine, structures are present among others in glycosphingolipids or H-II type, polyglycosylceramides and polyglycosylpeptides, e.g. erythroglycan ?
-
 ?
2.4.1.150 additional information Homo sapiens initiates formation of side chains, key enzyme in biosynthesis of I antigen of erythrocytes, N-acetyllactosamine is a more physiological acceptor than lactose ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.149 Homo sapiens
-
-
-
2.4.1.150 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.149 serum
-
 Homo sapiens
-
2.4.1.150 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.149 additional information the enzyme together with N-acetyllactosamine synthase, EC 2.4.1.90, catalyzes formation of linear glycans containing alternating beta-3-O-substituted residues of D-galactose and beta-4-O-substituted residues of N-acetyl-D-glucosamine, structures are present among others in glycosphingolipids or H-II type, polyglycosylceramides and polyglycosylpeptides, e.g. erythroglycan Homo sapiens ?
-
 ?
2.4.1.149 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?
2.4.1.149 UDP-N-acetylglucosamine + lactose less physiological acceptor than N-acetyllactosamine Homo sapiens UDP + GlcNAcbeta(1-3)Galbeta(1-4)Glc
-
 ?
2.4.1.149 UDP-N-acetylglucosamine + N-acetyllactosamine more physiological acceptor than lactose Homo sapiens UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc
-
 ?
2.4.1.150 additional information initiates formation of side chains, key enzyme in biosynthesis of I antigen of erythrocytes, N-acetyllactosamine is a more physiological acceptor than lactose Homo sapiens ?
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + asialo-alpha1-acid glycoprotein acts on beta-galactosyl-1,4-N-acetylglucosaminyl-termini on asialo-alpha1-acid glycoproteins Homo sapiens UDP + N-acetylglucosaminylated asialo-alpha1-acid glycoprotein
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R acts on beta-galactosyl-1,4-N-acetylglucosaminyl-termini on asialo-alpha1-acid glycoproteins Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + lactose
-
 Homo sapiens UDP + GlcNAcbeta(1-6)Galbeta(1-4)Glc
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + N-acetyllactosamine
-
 Homo sapiens UDP + GlcNAcbeta(1-6)Galbeta(1-4)GlcNAc
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.149 37
-
 assay at Homo sapiens
2.4.1.150 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.149 6.8 7.8 broad Homo sapiens
2.4.1.150 6.8 7.8 broad Homo sapiens