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Literature summary extracted from

  • Naguib, F.N.M.; El Kouni, M.H.; Chu, S.H.; Cha, S.
    New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers (1987), Biochem. Pharmacol., 36, 2195-2201.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 5-(3'-Benzyloxybenzyl)-1-[(1'-aminomethyl-2'-hydroxyethoxy)methyl]uracil
-
 Homo sapiens
2.4.2.3 5-(3'-Benzyloxybenzyl)-1-[(1'-aminomethyl-2'-hydroxyethoxy)methyl]uracil
-
 Mus musculus
2.4.2.3 Benzylacyclouridines
-
 Homo sapiens
2.4.2.3 Benzylacyclouridines
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.3 0.076
-
 phosphate
-
 Mus musculus
2.4.2.3 0.143
-
 uridine
-
 Mus musculus
2.4.2.3 0.242
-
 uridine
-
 Homo sapiens
2.4.2.3 0.279
-
 phosphate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 liver
-
 Mus musculus
-
2.4.2.3 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 uridine + phosphate
-
 Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.3 0.000018
-
 5-(3'-Benzyloxybenzyl)-1-[(1'-aminomethyl-2'-hydroxyethoxy)methyl]uracil
-
 Mus musculus