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Literature summary extracted from

  • Granovsky, M.; Bielfeldt, T.; Peters, S.; Paulsen, H.; Meldal, M.; Brockhausen, J.; Brockhausen, I.
    UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity synthesizing O-glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates (1994), Eur. J. Biochem., 221, 1039-1046.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.122 additional information proline on the C-terminal side of the peptide substrate adjacent to Thr(GalNAc) is inhibitory Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.122 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.122 UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R charge-charge interactions between enzyme and substrate Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.122 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine threonine alpha-D-galactosamine is preferred to serine alpha-D-galactosamine Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine Galbeta1,3-GalNAcalpha residues adjacent to Thr(GalNAc) reduces the activity Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine substrates with negatively charged amino acids on the N-terminal side are highly efficient substrates Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine glycosyl acceptor specificity study Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.122 core 1 beta3-Gal-T
-
 Rattus norvegicus