Literature summary extracted from

Alberg, D.G.; Bartlett, P.A.
Potent inhibition of 5-enolpyruvylshikimate-3-phosphate synthase by a reaction intermediate analogue (1989), J. Am. Chem. Soc., 111, 2337-2338.

No PubMed abstract available

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.19	Reaction intermediate analogue	-	Petunia x hybrida
2.5.1.19	shikimate 3-phosphate-5-carboxymethyl-(2R)-phosphonate	competitive vs. 5-enolpyruvylshikimate-3-phosphate and phosphate	Petunia x hybrida
2.5.1.19	shikimate 3-phosphate-5-carboxymethyl-(2S)-phosphonate	competitive vs. 5-enolpyruvylshikimate-3-phosphate and phosphate	Petunia x hybrida

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.19	Petunia x hybrida	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.19	phosphoenolpyruvate + 3-phosphoshikimate	-	Petunia x hybrida	phosphate + 5-enolpyruvylshikimate 3-phosphate	i.e. 5-O-(1-carboxyvinyl)-3-phosphoshikimate	r

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.5.1.19	0.000015	-	shikimate 3-phosphate-5-carboxymethyl-(2R)-phosphonate	vs. 5-enolpyruvylshikimate-3-phosphate	Petunia x hybrida
2.5.1.19	0.00009	-	shikimate 3-phosphate-5-carboxymethyl-(2R)-phosphonate	vs. phosphate	Petunia x hybrida
2.5.1.19	0.0011	-	shikimate 3-phosphate-5-carboxymethyl-(2S)-phosphonate	vs. 5-enolpyruvylshikimate-3-phosphate	Petunia x hybrida
2.5.1.19	0.0021	-	shikimate 3-phosphate-5-carboxymethyl-(2S)-phosphonate	vs. phosphate	Petunia x hybrida

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Release 2023.1 (January 2023)