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Literature summary extracted from

  • Queen, S.A.; Vander Jagt, D.L.; Reyes, P.
    Characterization of adenine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum (1989), Biochim. Biophys. Acta, 996, 160-165.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.7 2,6-diaminopurine competitive Plasmodium falciparum
2.4.2.7 6-Mercaptopurine competitive Plasmodium falciparum
2.4.2.7 Cd2+
-
 Plasmodium falciparum
2.4.2.7 Co2+
-
 Plasmodium falciparum
2.4.2.7 Hg2+
-
 Plasmodium falciparum
2.4.2.7 additional information no inhibition by iodoacetamide, DTNB Plasmodium falciparum
2.4.2.7 N-ethylmaleimide no inhibition Plasmodium falciparum
2.4.2.7 p-chloromercuribenzoate no inhibition Plasmodium falciparum
2.4.2.7 Zn2+ weak Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.7 0.0007
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum
2.4.2.7 0.0008
-
 adenine
-
 Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.7 18000
-
 gel filtration Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.7 Plasmodium falciparum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.7 trophozoite
-
 Plasmodium falciparum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.7 0.00000004
-
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.7 adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum AMP + diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.7 9
-
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.7 0.7
-
 Mercaptopurine
-
 Plasmodium falciparum
2.4.2.7 1
-
 2,6-diaminopurine
-
 Plasmodium falciparum