EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.2.22 | medicine | the enzyme lacks a mammalian counterpart and is, therefore, a potential target for antiparasitic therapy | Leishmania donovani |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.2.22 | expression in Escherichia coli | Leishmania donovani |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.22 | 0.0071 | - |
xanthine | - |
Leishmania donovani | |
2.4.2.22 | 0.448 | - |
hypoxanthine | - |
Leishmania donovani |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.22 | Leishmania donovani | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.22 | - |
Leishmania donovani |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.22 | 5-phospho-alpha-D-ribose 1-diphosphate + guanine | - |
Leishmania donovani | GMP + diphosphate | - |
? | |
2.4.2.22 | 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine | - |
Leishmania donovani | IMP + diphosphate | - |
? | |
2.4.2.22 | 5-phospho-alpha-D-ribose 1-diphosphate + xanthine | - |
Leishmania donovani | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.22 | 2.6 | - |
hypoxanthine | - |
Leishmania donovani | |
2.4.2.22 | 3.5 | - |
xanthine | - |
Leishmania donovani |