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Literature summary extracted from
- Role of poly(ADP-ribose) formation in DNA repair (1992), Nature, 356, 356-358.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.30 | DNA | enzyme has an N-terminal binding domain | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.30 | additional information | Homo sapiens | role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.30 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.30 | additional information | role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes | Homo sapiens | ? | - |
? | |
| 2.4.2.30 | NAD+ + (ADP-D-ribosyl)n-acceptor | auto-poly(ADP-ribosyl)ation | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
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Release 2023.1 (January 2023)
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