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Literature summary extracted from

  • De Murcia, G.; Huletsky, A.; Poirier, G.G.
    Modulation of chromatin structure by poly(ADP-ribosyl)ation (1988), Biochem. Cell Biol., 66, 626-635.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.30 DNA the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 nucleus
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 Bos taurus 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Bos taurus cuts produced in vivo on DNA during DNA repair activate the enzyme, which then synthesiszes poly(ADP-ribose) on histone H1, in particular, and contributes to the opening of the 25 nm chromatin fiber, resulting in the increased accessibility of DNA to excision repair enzymes ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information cuts produced in vivo on DNA during DNA repair activate the enzyme, which then synthesiszes poly(ADP-ribose) on histone H1, in particular, and contributes to the opening of the 25 nm chromatin fiber, resulting in the increased accessibility of DNA to excision repair enzymes Bos taurus ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of histone H1 Bos taurus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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 ?