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Literature summary extracted from

  • Awasthi, Y.C.; Singh, S.V.
    Purification and characterization of a new form of glutathione S-transferase from human erythrocytes (1984), Biochem. Biophys. Res. Commun., 125, 1053-1060.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 bromosulfophthalein inhibits only minor form, but not major form Homo sapiens
2.5.1.18 Hematin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 additional information
-
 additional information
-
 Homo sapiens
2.5.1.18 0.5
-
 glutathione major form Homo sapiens
2.5.1.18 0.6
-
 1-chloro-2,4-dinitrobenzene major form Homo sapiens
2.5.1.18 1.9
-
 1-chloro-2,4-dinitrobenzene minor form Homo sapiens
2.5.1.18 2
-
 glutathione minor form Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 45000
-
 erythrocytes, minor form Homo sapiens
2.5.1.18 47000
-
 erythrocytes, major form Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene enzyme has only weak activity towards the substrate Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 4-nitrobenzyl chloride
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + bromosulfophthalein
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + cumene hydroperoxide
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + ethacrynic acid
-
 Homo sapiens ?
-
 ?
2.5.1.18 additional information specificity Homo sapiens ?
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Homo sapiens HX + R-S-glutathione
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.18 4.5
-
 1-chloro-2,4-dinitrobenzene minor enzyme form Homo sapiens
2.5.1.18 7.67
-
 glutathione minor enzyme form Homo sapiens
2.5.1.18 12.2
-
 glutathione major enzyme form Homo sapiens
2.5.1.18 18.3
-
 1-chloro-2,4-dinitrobenzene major enzyme form Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.18 0.002
-
 Hematin major form Homo sapiens
2.5.1.18 0.032
-
 Hematin minor form Homo sapiens
2.5.1.18 0.068
-
 bromosulfophthalein minor form Homo sapiens