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Literature summary extracted from

  • Guthenberg, C.; Warholm, M.; Rane, A.; Mannervik, B.
    Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta (1986), Biochem. J., 235, 741-745.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 bromosulfophthalein
-
 Homo sapiens
2.5.1.18 Hematin
-
 Homo sapiens
2.5.1.18 Tributyltin acetate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 23000
-
 2 * 23000, acidic isoenzyme, SDS-PAGE Homo sapiens
2.5.1.18 25000
-
 2 * 25000, basic isoenzyme, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens
-
 basic and acid isoenzyme
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 an acidic and a basic form Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 16.4
-
-
 Homo sapiens
2.5.1.18 87
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + cumene hydroperoxide
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + ethacrynic acid
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + styrene oxide
-
 Homo sapiens ?
-
 ?
2.5.1.18 additional information specificity Homo sapiens ?
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Homo sapiens HX + R-S-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 dimer 2 * 23000, acidic isoenzyme, SDS-PAGE Homo sapiens
2.5.1.18 dimer 2 * 25000, basic isoenzyme, SDS-PAGE Homo sapiens