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Literature summary extracted from

  • Morgenstern, R.; Meijer, J.; DePierre, J.W.; Ernster, L.
    Characterization of rat-liver microsomal glutathione S-transferase activity (1980), Eur. J. Biochem., 104, 167-174.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.18 N-ethylmaleimide 8fold Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 0.0006
-
 glutathione not activated Rattus norvegicus
2.5.1.18 0.001 0.002 glutathione activated with N-ethylmaleimide Rattus norvegicus
2.5.1.18 0.006
-
 1-chloro-2,4-dinitrobenzene not activated Rattus norvegicus
2.5.1.18 0.03
-
 1-chloro-2,4-dinitrobenzene activated with N-ethylmaleimide Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 endoplasmic reticulum exposed on cytoplasmic surface Rattus norvegicus 5783
-
2.5.1.18 microsome
-
 Rattus norvegicus
-
-
2.5.1.18 additional information microsomal enzyme is clearly distinct from cytosolic Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.18 RX + glutathione Rattus norvegicus microsomal enzyme is likely to be involved in drug metabolism HX + R-S-glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene at a low rate Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Rattus norvegicus HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione microsomal enzyme is likely to be involved in drug metabolism Rattus norvegicus HX + R-S-glutathione
-
 ?