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Literature summary extracted from

  • Cameron, H.S.; Szczepaniak, D.; Weston, B.W.
    Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms (1995), J. Biol. Chem., 270, 20112-20122.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.65 membrane
-
 Homo sapiens 16020
-
2.4.1.152 membrane
-
 Homo sapiens 16020
-
2.4.1.152 membrane type II membrane protein, membrane-bound form in trans cistermae of Golgi Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.152 43008
-
 1 * 43008, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.65 GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R Homo sapiens the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
2.4.1.152 additional information Homo sapiens the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.65 Homo sapiens P21217
-
-
2.4.1.152 Homo sapiens P51993
-
-
2.4.1.152 Homo sapiens Q11128
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.65 liver
-
 Homo sapiens
-
2.4.1.152 colon
-
 Homo sapiens
-
2.4.1.152 kidney
-
 Homo sapiens
-
2.4.1.152 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.65 GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme Homo sapiens GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
2.4.1.152 additional information the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.152 monomer
-
 Homo sapiens
2.4.1.152 monomer 1 * 43008, calculation from nucleotide sequence Homo sapiens